What's in it?

Sugar Free Me™ is a herbal supplement, all natural and plant powered. The main ingredient is a herb called Gymnema Sylvestre, a noble leaf from India. 

Gymnema sylvestre[1] is a perennial woody vine that grows in tropical areas of India, Africa, and Australia and has been used for medicinal purposes in Ayurvedic medicine. Common names include gymnema,[2] Australian cowplant, and Periploca of the woods, and the Hindi term gurmar which means “sugar destroyer.” [3][4][5]

The leaves and extracts contain gymnemic acids, the major bioactive constituents that interact with taste receptors on the tongue to temporarily suppress the taste of sweetness.[6][7][8][9][10]

Description

The plant is a climber with leaves having soft hairs on the upper surface. The leaves are elongate oval shaped. It has small yellow umbelliferous inflorescence which is produced throughout the year.[11]

Properties

Gymnema sylvestre has a long history of use in herbal medicine and a broad range of therapeutic properties.[4][5][12]

Gymnema sylvestre leaves contain triterpenoid saponins,[13][14][15] flavonols,[16] and gurmarin.[5] The major biologically active plant molecules are gymnemic acids, a class of triterpenoid saponins, which have the effect of suppressing the taste of sweetness on the tongue from sucrose (sugar), stevia, xylitol, and artificial sweeteners such as aspartame.[17]

The sweet-blocking effect of Gymnema sylvestre lasts from 15 minutes[6] to 50 minutes[18] and may even persist for several hours.[19] There is no indication that gymnemic acids have long-term effects on taste and they do not influence bitter, salty, and sour taste perception.[7][20]

    Vernacular Indic names

      • Bengali meshashrunga - মেষশৃঙ্গ
      • tamachek Taemoerzôrt .
      • Gujarati gudmar - ગુડમાર, madhunashini - મધુનાશિની
      • Hindi gurmar - गुड़मार
      • Kannada madhunashini - ಮಧುನಾಶಿನಿ
      • Konkani kawli - कौळी
      • Malayalam chakkarakolli - ചക്കരക്കൊല്ലി
      • Marathi bedakicha pala - बेडकीचा पाला, gudmar - गुडमार
      • Oriya lakshmi - ଲକ୍ଷ୍ମୀ, mendhasingia - ମେଣ୍ଢା ଶିଙ୍ଗିଆ, nagapushpi - ନାଗପୁଷ୍ପୀ
      • Sanskrit madhunaashini - मधुनाशिनी, meshasringa - मेषशृंग
      • Sinhala මස්බැද්ද - Masbaedda
      • Tamil sirukurinjan - சிறுகுறிஞ்சா, kokilam, கோகிலம்
      • Telugu Podapatri - పొడపత్రి
      • Urdu gurmar - گڑمار [26]

    Etymology

    Gymnema sylvestre

    Gymnema derives from the Greek words "gymnos" (γυμνὀς) and "nēma" (νῆμα) meaning "naked" and "thread" respectively; the species epithetonsylvestre means "of the forest" in Latin.[27]

    The Hindi name Gurmar, Sanskrit Madhunashini, Urdu Gurmar, Malayalam Chakkarakolli and Telugu Podapatri, literally means "sugar destroyer". (Sanskrit) Meshasringa translates as "ram's horn", a name given to the plant due to the shape of its fruits.

    References

    1. "Integrated Taxonomic Information System"www.itis.gov. Retrieved 2018-02-01.
    2. Duke JA, ed. (2002). Handbook of medicinal herbs (2nd ed.). CRC Press. p. 855. ISBN 0-8493-1284-1.
    3. Quattrocchi U (1999-11-23). CRC World Dictionary of Plant Names: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology. Taylor & Francis US. ISBN 9780849326769.
    4. Tiwari P, Mishra BN, Sangwan NS (2014). "Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant"BioMed Research International2014: 830285. doi:10.1155/2014/830285PMC 3912882Freely accessiblePMID 24511547.
    5. Ulbricht C, Abrams TR, Basch E, Davies-Heerema T, Foppa I, Hammerness P, Rusie E, Tanguay-Colucci S, Taylor S, Ulbricht C, Varghese M, Weissner W, Woods J (2011). "An evidence-based systematic review of gymnema (Gymnema sylvestre R. Br.) by the Natural Standard Research Collaboration". Journal of Dietary Supplements8 (3): 311–30. doi:10.3109/19390211.2011.597977PMID 22432729.
    6. Kurihara Y (1969). "Antisweet activity of gymnemic acid A1 and its derivatives". Life Sciences8 (9): 537–43. doi:10.1016/0024-3205(69)90449-4PMID 5791706.
    7. Gent JF, Hettinger TP, Frank ME, Marks LE (1999). "Taste confusions following gymnemic acid rinse". Chemical Senses24 (4): 393–403. doi:10.1093/chemse/24.4.393PMID 10480675.
    8. Sanematsu K, Kusakabe Y, Shigemura N, Hirokawa T, Nakamura S, Imoto T, Ninomiya Y (September 2014). "Molecular mechanisms for sweet-suppressing effect of gymnemic acids"The Journal of Biological Chemistry289 (37): 25711–20. doi:10.1074/jbc.M114.560409PMC 4162174Freely accessiblePMID 25056955.
    9. Gardner Z, McGuffin M (2013-03-15). American Herbal Products Association’s Botanical Safety Handbook, Second Edition. CRC Press. ISBN 9781466516946.
    10. Brala PM, Hagen RL (January 1983). "Effects of sweetness perception and caloric value of a preload on short term intake". Physiology & Behavior30 (1): 1–9. PMID 6836034.
    11. Drury H (1869). Hand-book of Indian Flora. Madras: Trabancore Sircar Press. p. 232. ISBN 978-1-143-66359-8.
    12. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS (April 2003). "Systematic review of herbs and dietary supplements for glycemic control in diabetes". Diabetes Care26 (4): 1277–94. PMID 12663610.
    13. Dateo GP, Long L (September 1973). "Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on the isolation and heterogeneity of gymnemic acid A1". Journal of Agricultural and Food Chemistry21 (5): 899–903. PMID 4733385.
    14. Di Fabio G, Romanucci V, Di Marino C, Pisanti A, Zarrelli A (2015). "Gymnema sylvestre R. Br., an Indian medicinal herb: traditional uses, chemical composition, and biological activity". Current Pharmaceutical Biotechnology16 (6): 506–16. PMID 25860062.
    15. Sinsheimer JE, McIlhenny HM (1967). "Constituents from Gymnema sylvestre leaves. II. Nitrogenous compounds". Journal of Pharmaceutical Sciences56 (6): 732–6. doi:10.1002/jps.2600560615PMID 6039815.
    16. Liu X, Ye W, Yu B, Zhao S, Wu H, Che C (March 2004). "Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata". Carbohydrate Research339 (4): 891–5. doi:10.1016/j.carres.2003.12.017PMID 14980834.
    17. Frank RA, Mize SJ, Kennedy LM, de los Santos HC, Green SJ (1992-10-01). "The effect of Gymnema sylvestre extracts on the sweetness of eight sweeteners"Chemical Senses17 (5): 461–479. doi:10.1093/chemse/17.5.461.
    18. Meiselman HL, Halperin BP (1970). "Human judgments of Gymnema sylvestre and sucrose mixtures". Physiology & Behavior5 (8): 945–8. doi:10.1016/0031-9384(70)90187-3PMID 5522511.
    19. US application 2004071801, Edell D, Handel R, "Herbal formulation of Gymnema sylvestre as a dietary aid", published 15 April 2004
    20. Riskey DR, Desor JA, Vellucci D (1982-01-01). "Effects of gymnemic acid concentration and time since exposure on intensity of simple tastes: A test of the biphasic model for the action of gymnemic acid"Chemical Senses7 (2): 143–152. doi:10.1093/chemse/7.2.143ISSN 0379-864X.
    21. Clinical trial number NCT02744885 for "Crave Crush Behavioral Study" at ClinicalTrials.gov
    22. Stice E, Yokum S, Gau JM (2017). "Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment". Journal of Psychopharmacology31 (11): 1496–1502. doi:10.1177/0269881117728541PMID 28944714.
    23. Nobel S, Baker C, Loullis C (November 2017). "Crave CrushTM lozenges containing gymnemic acids reduce consumption of high sugar foods"Advancement in Medicinal Plant Research5 (4).
    24. Ogawa Y, Sekita K, Umemura T, Saito M, Ono A, Kawasaki Y, Uchida O, Matsushima Y, Inoue T, Kanno J (February 2004). "[Gymnema sylvestre leaf extract: a 52-week dietary toxicity study in Wistar rats]". Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan45 (1): 8–18. PMID 15168555.
    25. Ueno M (1993). "The bioactivity and use of the sugar absorption inhibitor "Gymnema sylvestre"". Technical Journal On Food Chemistry & Chemicals12: 21–26.
    26. "Gurmar"Flowers of India. Retrieved 24 October 2016.
    27. Wikisource:The New International Encyclopædia/Gymnema
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    30. Tiwari, Pragya (2014) "Phytochemical and Pharmacological Properties of Gymnema sylvestre: An Important Medicinal Plant" BioMed Research International.
    31. Group, Edward (21 October 2015) "The Weight Loss Benefits of Gymnema". Retrieved 17 July 2018 from globalhealingcenter.com.
    32. "Effect of Extended Release Gymnema Sylvestre Leaf Extract".  6 January 2011. Diabetes in Control Newsletter.
    33. Natural Health Sherpa. 18 March 2011. Gymnema Sylvestre: A Natural Way to Curb Cravings and Balance Blood SugarRetrieved from www.youtube.com on 17 July 2018.
    34. "Ayurvedic Medicine: the Multiple Benefits of Gymnema Sylvestre" 21 August 2017. Retrieved from nutranews.org on 17 July 2018.
    35. Sanematsu, Keisuke (12 September 2014) "Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids". Journal of Biological Chemistry.